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First Experience Addressing the Prognostic Utility of Novel Urinary Biomarkers in Patients With COVID-19.

Tantry, Udaya S; Bliden, Kevin P; Cho, Alastair; Walia, Naval; Dahlen, Jeffrey R; Ens, Gordon; Traianova, Malina; Jerjian, Christophe; Usman, Abira; Gurbel, Paul A.

Open Forum Infect Dis ; 8(7): ofab274, 2021 Jul.

Article in English | MEDLINE | ID: covidwho-1305437

ABSTRACT

Urine 11-dehydro-thromboxane B2 (u11-dh-TxB2), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and liver-type fatty acid binding protein levels (L-FABP) at the time of hospitalization were higher in coronavirus disease 2019 (COVID-19) patients with adverse events vs without events. Higher u11-dh-TxB2 and L-FABP levels were associated with longer hospitalization, more thrombotic events, and greater mortality, providing evidence for potential utility as early prognostic biomarkers for COVID-19.

IS LOW DOSE ASPIRIN EFFECTIVE IN REDUCING IN-HOSPITAL CLINICAL OUTCOMES IN PATIENTS WITH COVID-19?

Gurbel, Paul A.; Bliden, Kevin, Walia, Naval, Rapista, Nicole, Ens, Gordon, Barnes, Jamie, Navarese, Eliano, Tantry, Udaya.

Journal of the American College of Cardiology ; 77(18, Supplement 1):3083, 2021.

Article in English | ScienceDirect | ID: covidwho-1213735

Bedside thromboelastography to rapidly assess the pharmacodynamic response of anticoagulants and aspirin in COVID-19: evidence of inadequate therapy in a predominantly minority population.

Gurbel, Paul A; Bliden, Kevin P; Rout, Amit; Rapista, Nicole; Walia, Naval; Chaudhary, Rahul; Ens, Gordon; Traianova, Malina; Barnes, Jaime S; Tantry, Udaya S.

J Thromb Thrombolysis ; 51(4): 902-904, 2021 May.

Article in English | MEDLINE | ID: covidwho-1170900

Subject(s)

Anticoagulants , Aspirin , Biomarkers, Pharmacological/blood , COVID-19 Drug Treatment , COVID-19 , Heparin , Point-of-Care Testing/statistics & numerical data , Thrombelastography/methods , Black or African American/statistics & numerical data , Anticoagulants/administration & dosage , Anticoagulants/pharmacokinetics , Aspirin/administration & dosage , Aspirin/pharmacokinetics , Biological Availability , COVID-19/blood , COVID-19/diagnosis , COVID-19/physiopathology , Female , Hemostasis/drug effects , Hemostasis/physiology , Heparin/administration & dosage , Heparin/pharmacokinetics , Humans , Male , Middle Aged , Platelet Aggregation Inhibitors/administration & dosage , Platelet Aggregation Inhibitors/pharmacokinetics , Platelet Function Tests/methods , Platelet Function Tests/statistics & numerical data , SARS-CoV-2 , United States/epidemiology

ABSTRACT

Subject(s)

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